Safer opioid painkiller made from scratch
A brand new technique of creating painkillers could result in various medicines with out the unintended effects, say researchers. Credit score: © stevecuk / Fotolia A global crew of researchers -- led by scientists at UC San Francisco, Stanford College, the College of North Carolina (UNC), and the Friedrich-Alexander College Erlangen-Nürnberg in Germany -- has developed a brand new opioid drug candidate that blocks ache with out triggering the damaging unintended effects of present prescription painkillers. Their secret? Ranging from scratch -- with computational methods that allow them discover greater than 4 trillion completely different chemical interactions. In a brand new research -- printed on-line August 17, 2016 in Nature -- the researchers used the newly deciphered atomic construction of the mind's "morphine receptor" to custom-engineer a novel drug candidate that blocked ache as successfully as morphine in mouse experiments, however didn...